Recently, the Department of Tropical Diseases, Thai Nguyen Central Hospital has received and cured for the patient, Mr. T.V.T.(58 years old, in Phu Binh, Thai Nguyen).The patient was hospitalized in a state of high fever, the whole body was scattered, ulcers of the mucosa in the lips, mouth and genitals.

Through careful examination and exploitation of the history of the disease, patients T with a history of gout, anaphylaxis III (shocking reaction at a critical level) due to Allopurinol (a gout medication).

10 days earlier, the patient at home with joint pain went to the drugstor to buy gout drugs, including allopurinol.

After 3 days after drinking, Mr. T appeared fever.On the 7th day, the skin burns the skin, ulcers of the lip lip mucosa and the genital area.

Patients are diagnosed with severe physical allergies (Lyell syndrome) due to the use of allopurinol and are being actively treated in the Department of Tropical Diseases.

Lyell syndrome (also known as poisoned epidermal necrotic disease) is a disease in the slow drug allergy group, and is also the most serious disease in this group, the life of the patient is seriously threatened..

The disease is characterized by necrosis in the epidermis (the top layer of the skin) and then sliding this skin ulcer, caused by the toxic effect of allergens in the body, leading to the appearance of the appearanceSymptoms typical of the disease.The groups of drugs that often cause Lyell syndrome are: Gout (allopurinol), a group of neuropathic drugs (carbamazebin-tegretol), antibiotic and nonsteroidal antibiotics and nonsteroidal analgesics and drugsMale, Chinese medicine of unknown origin.

The doctor recommends that, when sick, people need to go to the doctor and use the prescription of the doctor, do not arbitrarily take the drug, so there should be a monitoring book to record suspected drugs or know it is sure to be allergies.When entering the hospital for the next time, patients need to notify the doctor and pharmacist about allergies and severity.